Publications

2026

  1. Degezelle, M. M., Chaami, C., Lewis, C. T. A., Zhang, C., Hessel, A. L., Rainer, P. P., Kirk, J. A., Stokke, M. K., Seaborne, R. A. E., & Ochala, J. (2026). Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus. Cardiovascular Diabetology. https://doi.org/10.1186/s12933-025-03052-5

2025

  1. Gerlach Melhedegaard, E., Rostedt, F., Gineste, C., Seaborne, R. A., Dugdale, H. F., Belhac, V., Zanoteli, E., Lawlor, M. W., Mack, D. L., Wallgren-Pettersson, C., Hessel, A. L., Jungbluth, H., Laporte, J., Saito, Y., Nishino, I., Ochala, J., & Laitila, J. (2025). Myosin inhibition partially rescues the myofiber proteome in X-linked myotubular myopathy. JCI Insight, 10(24), e194868. https://doi.org/10.1172/jci.insight.194868
  2. Jacques, M., Landen, S., Sharples, A. P., Garnham, A., Schittenhelm, R., Steele, J., Heikkinen, A., Sillanpää, E., Ollikainen, M., Broatch, J., Zarekookandeh, N., Hanson, O., Ekström, O., Asplund, O., Lamon, S., Alexander, S. E., Smith, C., Bauer, C., Woessner, M. N., … Eynon, N. (2025). Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration. Cell Reports, 44(6), 115750. https://doi.org/10.1016/j.celrep.2025.115750
  3. Seaborne, R. A. E., Moreno-Justicia, R., Laitila, J., Lewis, C. T. A., Savoure, L., Zanoteli, E., Lawlor, M. W., Jungbluth, H., Deshmukh, A. S., & Ochala, J. (2025). Integrated single-cell functional-proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof-of-principle study. Journal of Physiology, 603(10), 3033–3048. https://doi.org/10.1113/JP288363
  4. Lewis, C. T. A., Moreno-Justicia, R., Savoure, L., Calvo, E., Bak, A., Laitila, J., Seaborne, R. A. E., Larsen, S., Iwamoto, H., Cefis, M., Morais, J. A., Gouspillou, G., Alegre-Cebollada, J., Hawke, T. J., Vazquez, J., Adrover, M., Marcangeli, V., Hammad, R., Granet, J., … Ochala, J. (2025). Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus. Diabetologia, 68(8), 1836–1850. https://doi.org/10.1007/s00125-025-06436-0
  5. Moreno-Justicia, R., Van der Stede, T., Stocks, B., Laitila, J., Seaborne, R. A., Van de Loock, A., Lievens, E., Samodova, D., Marín-Arraiza, L., Dmytriyeva, O., Browaeys, R., Van Vossel, K., Moesgaard, L., Yigit, N., Anckaert, J., Weyns, A., Van Thienen, R., Sahl, R. E., Zanoteli, E., … Deshmukh, A. S. (2025). Human skeletal muscle fiber heterogeneity beyond myosin heavy chains. Nature Communications, 16(1), 1764. https://doi.org/10.1038/s41467-025-56896-6

2024

  1. Laitila, J., Seaborne, R. A. E., Ranu, N., Kolb, J. S., Wallgren-Pettersson, C., Witting, N., Vissing, J., Vilchez, J. J., Zanoteli, E., Palmio, J., Huovinen, S., Granzier, H., & Ochala, J. (2024). Myosin ATPase inhibition fails to rescue the metabolically dysregulated proteome of nebulin-deficient muscle. Journal of Physiology, 602(20), 5229–5245. https://doi.org/10.1113/JP286870
  2. Law, P. P., Mikheeva, L. A., Rodriguez-Algarra, F., Asenius, F., Gregori, M., Seaborne, R. A. E., Yildizoglu, S., Miller, J. R. C., Tummala, H., Mesnage, R., Antoniou, M. N., Li, W., Tan, Q., Hillman, S. L., Rakyan, V. K., Williams, D. J., & Holland, M. L. (2024). Ribosomal DNA copy number is associated with body mass in humans and other mammals. Nature Communications, 15(1), 5006. https://doi.org/10.1038/s41467-024-49397-5
  3. Lewis, C. T. A., Melhedegaard, E. G., Ognjanovic, M. M., Olsen, M. S., Laitila, J., Seaborne, R. A. E., Gronset, M., Zhang, C., Iwamoto, H., Hessel, A. L., Kuehn, M. N., Merino, C., Amigo, N., Frobert, O., Giroud, S., Staples, J. F., Goropashnaya, A. V., Fedorov, V. B., Barnes, B. M., … Ochala, J. (2024). Remodeling of skeletal muscle myosin metabolic states in hibernating mammals. ELife, 13, RP94616. https://doi.org/10.7554/eLife.94616
  4. Lewis, C. T. A., Melhedegaard, E. G., Ognjanovic, M. M., Olsen, M. S., Laitila, J., Seaborne, R. A. E., Gronset, M. N., Zhang, C., Iwamoto, H., Hessel, A. L., Kuehn, M. N., Merino, C., Amigo, N., Frobert, O., Giroud, S., Staples, J. F., Goropashnaya, A. V., Fedorov, V. B., Barnes, B. M., … Ochala, J. (2024). Remodelling of Skeletal Muscle Myosin Metabolic States in Hibernating Mammals. BioRxiv. https://doi.org/10.1101/2023.11.14.566992

2023

  1. Seaborne, R. A. E., & Ochala, J. (2023). The dawn of the functional genomics era in muscle physiology. Journal of Physiology, 601(8), 1343–1352. https://doi.org/10.1113/JP284206

2022

  1. Rodriguez-Algarra, F., Seaborne, R. A. E., Danson, A. F., Yildizoglu, S., Yoshikawa, H., Law, P. P., Ahmad, Z., Maudsley, V. A., Brew, A., Holmes, N., Ochôa, M., Hodgkinson, A., Marzi, S. J., Pradeepa, M. M., Loose, M., Holland, M. L., & Rakyan, V. K. (2022). Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states. Genome Biology, 23(1), 54. https://doi.org/10.1186/s13059-022-02617-x

2021

  1. Ruple, B. A., Godwin, J. S., Mesquita, P. H. C., Osburn, S. C., Vann, C. G., Lamb, D. A., Sexton, C. L., Candow, D. G., Forbes, S. C., Frugé, A. D., Kavazis, A. N., Young, K. C., Seaborne, R. A., Sharples, A. P., & Roberts, M. D. (2021). Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle. FASEB Journal, 35(9), e21864. https://doi.org/10.1096/fj.202100873RR
  2. Maasar, M. F., Turner, D. C., Gorski, P. P., Seaborne, R. A., Strauss, J. A., Shepherd, S. O., Cocks, M., Pillon, N. J., Zierath, J. R., Hulton, A. T., Drust, B., & Sharples, A. P. (2021). The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle. Frontiers in Physiology, 12, 619447. https://doi.org/10.3389/fphys.2021.619447
  3. Turner, D. C., Gorski, P. P., Seaborne, R. A., Viggars, M., Murphy, M., Jarvis, J. C., Martin, N. R. W., Stewart, C. E., & Sharples, A. P. (2021). Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo. Journal of Cellular Physiology, 236(9), 6534–6547. https://doi.org/10.1002/jcp.30328
  4. Hughes, D. C., Turner, D. C., Baehr, L. M., Seaborne, R. A., Viggars, M., Jarvis, J. C., Gorski, P. P., Stewart, C. E., Owens, D. J., Bodine, S. C., & Sharples, A. P. (2021). Knockdown of the E3 ubiquitin ligase UBR5 and its role in skeletal muscle anabolism. American Journal of Physiology - Cell Physiology, 320(1), C45–C56. https://doi.org/10.1152/ajpcell.00432.2020

2020

  1. Turner, D. C., Gorski, P. P., Maasar, M. F., Seaborne, R. A., Baumert, P., Brown, A. D., Kitchen, M. O., Erskine, R. M., Dos-Remedios, I., Voisin, S., Eynon, N., Sultanov, R. I., Borisov, O. V., Larin, A. K., Semenova, E. A., Popov, D. V., Generozov, E. V., Stewart, C. E., Drust, B., … Sharples, A. P. (2020). DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity. Scientific Reports, 10(1), 15360. https://doi.org/10.1038/s41598-020-72730-z
  2. Seaborne, R. A., & Sharples, A. P. (2020). The Interplay Between Exercise Metabolism, Epigenetics, and Skeletal Muscle Remodeling. Exercise and Sport Sciences Reviews, 48(4), 188–200. https://doi.org/10.1249/JES.0000000000000227

2019

  1. Venturelli, M., Schena, F., Naro, F., Reggiani, C., Pereira Guimarães, M., de Almeida Costa Campos, Y., Costa Moreira, O., Fernandes da Silva, S., Silva Marques de Azevedo, P. H., Dixit, A., Srivastav, S., Hinkley, J. M., Seaborne, R. A., Viggars, M., Sharples, A. P., Mahmassani, Z. S., Drummond, M. J., & Gondin, J. (2019). Commentaries on Viewpoint: "Muscle memory" not mediated by myonuclear number? Secondary analysis of human detraining data. Journal of Applied Physiology, 127(6), 1817–1820. https://doi.org/10.1152/japplphysiol.00754.2019
  2. Seaborne, R. A., Hughes, D. C., Turner, D. C., Owens, D. J., Baehr, L. M., Gorski, P., Semenova, E. A., Borisov, O. V., Larin, A. K., Popov, D. V., Generozov, E. V., Sutherland, H., Ahmetov, I. I., Jarvis, J. C., Bodine, S. C., & Sharples, A. P. (2019). UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy. Journal of Physiology, 597(14), 3727–3749. https://doi.org/10.1113/JP278073
  3. Hearris, M. A., Hammond, K. M., Seaborne, R. A., Stocks, B., Shepherd, S. O., Philp, A., Sharples, A. P., Morton, J. P., & Louis, J. B. (2019). Graded reductions in preexercise muscle glycogen impair exercise capacity but do not augment skeletal muscle cell signaling: implications for CHO periodization. Journal of Applied Physiology, 126(6), 1587–1597. https://doi.org/10.1152/japplphysiol.00913.2018
  4. Turner, D. C., Seaborne, R. A., & Sharples, A. P. (2019). Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory. Scientific Reports, 9(1), 4251. https://doi.org/10.1038/s41598-019-40787-0
  5. Turner, D. C., Kasper, A. M., Seaborne, R. A., Brown, A. D., Close, G. L., Murphy, M., Stewart, C. E., Martin, N. R. W., & Sharples, A. P. (2019). Exercising Bioengineered Skeletal Muscle In Vitro: Biopsy to Bioreactor. In Methods in Molecular Biology (Vol. 1889, pp. 55–79). Humana Press. https://doi.org/10.1007/978-1-4939-8897-6_5

2018

  1. Seaborne, R. A., Strauss, J., Cocks, M., Shepherd, S., O’Brien, T. D., van Someren, K. A., Bell, P. G., Murgatroyd, C., Morton, J. P., Stewart, C. E., Mein, C. A., & Sharples, A. P. (2018). Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining. Scientific Data, 5, 180213. https://doi.org/10.1038/sdata.2018.213
  2. Seaborne, R. A., Strauss, J., Cocks, M., Shepherd, S., O’Brien, T. D., van Someren, K. A., Bell, P. G., Murgatroyd, C., Morton, J. P., Stewart, C. E., & Sharples, A. P. (2018). Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy. Scientific Reports, 8(1), 1898. https://doi.org/10.1038/s41598-018-20287-3

2017

  1. Fisher, A. G., Seaborne, R. A., Hughes, T. M., Gutteridge, A., Stewart, C., Coulson, J. M., Sharples, A. P., & Jarvis, J. C. (2017). Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle. FASEB Journal, 31(12), 5268–5282. https://doi.org/10.1096/fj.201700089RR

2016

  1. Sharples, A. P., Stewart, C. E., & Seaborne, R. A. (2016). Does skeletal muscle have an ’epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise. Aging Cell, 15(4), 603–616. https://doi.org/10.1111/acel.12486
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